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Although it has been argued that acetyl-L carnitine is better than l-carnitine in absorption and activity, there has been no experiment to compare the two compounds at the same dose. In the present experiment, the effects of acetyl-L carnitine and L carnitine on the levels of free, acyl, and total L-carnitine in plasma and brain, rat ambulatory activity, and biomarkers of oxidative stress are investigated. Aged rats were given acetyl-L carnitine or L-carnitine at 0.15% in drinking water for 4 weeks. L-carnitine and acetyl-L carnitine were similar in elevating carnitine levels in plasma and brain. Both increased ambulatory activity similarly. However, acetyl-L carnitine decreased the lipid peroxidation in the old rat brain, while L-carnitine did not. Acetyl-L carnitine decreased the extent of oxidized nucleotides while L-carnitine did not. In conclusion, acetyl-L carnitine and L-carnitine were similar in increasing ambulatory activity in old rats and elevating carnitine levels in blood and brain. However, acetyl-L carnitine was effective, unlike L-carnitine, in decreasing oxidative damage in old rat brain. These data suggest that acetyl-L carnitine may be a better dietary supplement than L-carnitine.
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